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•ALG-2des23wt binds Ca2+ ions sequentially, with no apparent cooperativity.•ALG-2des23ΔGF122 binds Ca2+ with evidence of inter-subunit cooperativity.•Both isoforms possess a high-affinity (K>5×104M−1) binding-site for Mg2+.•The high-affinity Mg2+ site exhibits atypically low affinity for Ca2+.•The Mg2+-binding site is believed to reside in the EF5 binding loop.
Rat β-parvalbumin (β-PV) displays low divalent-ion affinity. Its CD site is distinguished by six non-consensus residues – the “CD-loop residues” – at positions 49, 50, 57–60. Additionally, leucine occupies position 85, rather than phenylalanine, the β-lineage-consensus residue. Replacement of the CD-loop residues in rat β with the canonical residues was previously found to have little effect on divalent-ion...
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