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The heme-regulated eIF2α kinase (HRI) phosphorylates the α subunit of the translation initiation factor 2, which plays an important role in translational regulation during heme deficiency. HRI is expressed mainly in erythroid cells. To elucidate the mechanisms that regulate the tissue-specific expression of the mouse HRI gene, we have cloned and characterized its 5' flanking region. Primer extension...
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