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In non-small-cell lung cancer (NSCLC) that harbours an activating epidermal growth factor receptor (EGFR) mutation, over-expression of hepatocyte growth factor (HGF) is an important mechanism involved in the acquired resistance to EGFR-tyrosine kinase inhibitors (TKIs) by restoring activity of the PI3K/Akt pathway via phosphorylation of MET. In our study, we found that the forced expression of miR-34a...
Tumor size at diagnosis (TSD) indirectly reflects tumor growth rate. The relationship between TSD and smoking is poorly understood. The aim of the study was to determine the relationship between smoking and TSD. We reviewed 1712 newly diagnosed and previously untreated non-small cell lung cancer (NSCLC) patients’ electronic medical records and collected tumor characteristics. Demographic and epidemiologic...
BACKGROUND:The efficacy of computed tomography (CT) screening for lung cancer remains controversial because results from the National Lung Screening Trial are not yet available. In this study, the authors used data from a single‐arm CT screening trial to estimate the mortality reduction using a modeling‐based approach to construct a control comparison arm.
METHODS:To estimate the potential lung cancer...
In this paper, we proposed a novel non-invasive electronic nose for detection and diagnosis of lung cancer based on an electronic nose instrument which includes a gas extraction and capillary column to concentrate, desorb and separate volatile organic compounds (VOCs) in patientspsila breath, respectively. Surface Acoustic Wave (SAW) gas sensors was used to detect chemical compounds. The specific...
In this paper, we propose a non-invasive detection method of lung cancer combined with a sort of virtual SAW gas sensors array and imaging recognition method. A patient's breath goes through an electronic nose with solid phase micro extraction (SPME) and capillary column for pre-concentration and separation of volatile organic compounds (VOCs) respectively, a pair of SAW sensors one coated with a...
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