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Structure–activity relationships around a novel series of B-Raf V600E inhibitors are reported. The enzymatic and cellular potencies of inhibitors derived from two related hinge-binding groups were compared and3-methoxypyrazolopyridine proved to be superior. The 3-alkoxy group of lead B-Raf V600E inhibitor 1 was extended and minimally affected potency. The propyl sulfonamide tail of...
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