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Increasing evidence shows that protein phosphorylation on serine (Ser), threonine (Thr) and tyrosine (Tyr) residues is a major regulatory post‐translational modification in the bacteria. To reveal the phosphorylation state in the Gram‐negative pathogenic bacterium Helicobacter pylori, we carried out a global and site‐specific phosphoproteomic analysis based on TiO2‐phosphopeptide enrichment and high‐accuracy...
Gold(III) porphyrin 1a is a novel gold(III) complex with selective anticancer effect in a number of human carcinoma cell lines. We have previously shown that gold(III) porphyrin 1a mediated mitochondrial transmembrane potential (ΔΨm) depletion, leading to cytochrome c release, nucleus translocation of apoptosis-inducing factor (AIF), and generation of reactive oxygen species (ROS). The current study...
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