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Binding surfaces of the type II transforming growth factor (TGF)-β receptor extracellular domain (TβRII-ECD) are mapped by combining scanning-deletion mutagenesis results with knowledge-based modeling of the ectodomain structure. Of the 17 deletion mutants produced within the core binding domain of TβRII-ECD, only three retained binding to TGF-β. Comparative modeling based on the crystal structure...
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