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Recently, targeted delivery systems based on functionalized polymeric nanoparticles have attracted a great deal of attention in cancer diagnosis and therapy. Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible...
Ligand‐modified, gene‐loaded nanoparticles (NPs) are designed and prepared as a tumor‐targeting theranostic agent by I. C. Kwon, K. Y. Lee, and co‐workers. The nanoparticles offer neuroblastoma‐specific in‐vivo optical imaging, and adding a therapeutic gene cocktail into the NPs could play a critical role for gene‐therapy‐based on RNAi. On page 1201, dye‐labeled NPs are modified with rabies virus...
The development of safe and efficient diagnostic/therapeutic agents for treating cancer in clinics remains challenging due to the potential toxicity of conventional agents. Although the annual incidence of neuroblastoma is not that high, the disease mainly occurs in children, a population vulnerable to toxic contrast agents and therapeutics. We demonstrate here that cancer-targeting, gas-generating...
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