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The direct visualisation of bacteria in the distal lung would increase the spatiotemporal understanding of pulmonary infection and be a powerful tool to stratify patients with suspected pneumonia. In critically ill patients, the diagnostic dilemma of pulmonary opacities leads to overprescribing of antimicrobial agents while waiting for culture results from bronchoalveolar lavage. Ubiquicidin (UBI)...
Acute respiratory distress syndrome is a severe and heterogeneous condition. Clinical diagnostic criteria lack specificity and fail to differentiate the various inflammatory phenotypes. Diagnosis and stratification can be improved by profiling the neutrophil and one of its enzymes, neutrophil elastase (NE), within the alveolar space. We aimed to combine fibre-based optical endomicroscopy (OEM) with...
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