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Tubulin‐based nanotubes (TNTs) to deliver microtubule‐targeting agents (MTAs) for clinical oncology are reported. Three MTAs, docetaxel (DTX), laulimalide (LMD), and monomethyl auristatin E (MMAE), which attach to different binding sites in a tubulin, are loaded onto TNTs and cause structural changes in them, including shape anisotropy and tubulin layering. This drug‐driven carrier transformation...
In article number 2002902, Sangyong Jon, Myung Chul Choi, and co‐workers develop tubulin‐based nanotubes (TNTs) as a delivery platform for microtubule‐targeting agents with a strategy of using a target protein as a carrier. Three types of TNT structures—ring TNTs (RTNTs), single‐walled TNTs (SWTNTs), and double‐walled TNT (DWTNTs)—can be used to deliver a variety of anticancer drugs to cellular microtubules...
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