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To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8α+ DEC‐205+ or CD8α− DCIR2+ DC along with a clinically feasible adjuvant, poly IC. By studying Y. pestis in mice, we could evaluate the capacity of this targeting approach to protect against a human pathogen. The DEC‐targeted LcrV induced polarized Th1 immunity, whereas DCIR2‐targeted...
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