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While immunotherapy has a tremendous clinical potential to combat cancer, immune responses generated by conventional cancer immunotherapy remain not enough to completely eliminate tumors, mainly due to the tumor's immunosuppressive microenvironment and heterogeneity of tumor immunogenicity. To improve antitumor immune responses and realize personalized immunotherapy, in this report, endogenous tumor...
In article number 1801372, Hongling Zhang, Zhenzhong Zhang, and co‐workers show that, under local ultrasound treatment, nano Fe3O4 particles (∼10 nm) are released from Ce6/Fe3O4‐L specifically within the tumor. Due to the excellent protein‐bound efficiency and lymph node (LN)‐targeting ability, endogenous tumor antigens are captured and transported to the LNs, thus potentiating cancer immunotherapy...
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