Nicholas L. Abbott

article

Polymeric Films Containing Sodium Chlorite That Release Disinfectant Gas upon Activation with UV Light

Reza Abbasi, Rishabh Jain, Kevin Nelson, David Busche, more

Advanced Functional Materials > 29 > 7 > n/a - n/a

Polymeric films that release disinfectant gas on demand have the potential to be useful for management of microbial burden (e.g., sterilization). Past attempts to create such films, however, have suffered from the need for stringent control over moisture or exposure to visible light prior to use. It is reported that polyvinyl alcohol (PVA) or polyolefin (POD) films that contain NaClO₂ crystals can...

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Redox‐Triggered Orientational Responses of Liquid Crystals to Chlorine Gas

Tibor Szilvási, Nanqi Bao, Karthik Nayani, Huaizhe Yu, more

Angewandte Chemie International Edition > 57 > 31 > 9665 - 9669

Surface‐supported liquid crystals (LCs) that exhibit orientational and thus optical responses upon exposure to ppb concentrations of Cl₂ gas are reported. Computations identified Mn cations as candidate surface binding sites that undergo redox‐triggered changes in the strength of binding to nitrogen‐based LCs upon exposure to Cl₂ gas. Guided by these predictions, μm‐thick films of nitrile‐ or pyridine‐containing...

article

Redox‐Triggered Orientational Responses of Liquid Crystals to Chlorine Gas

Tibor Szilvási, Nanqi Bao, Karthik Nayani, Huaizhe Yu, more

Angewandte Chemie > 130 > 31 > 9813 - 9817

Surface‐supported liquid crystals (LCs) that exhibit orientational and thus optical responses upon exposure to ppb concentrations of Cl₂ gas are reported. Computations identified Mn cations as candidate surface binding sites that undergo redox‐triggered changes in the strength of binding to nitrogen‐based LCs upon exposure to Cl₂ gas. Guided by these predictions, μm‐thick films of nitrile‐ or pyridine‐containing...

article

Liquid Crystals with Interfacial Ordering that Enhances Responsiveness to Chemical Targets

Karthik Nayani, Prabin Rai, Nanqi Bao, Huaizhe Yu, more

Advanced Materials > 30 > 27 > n/a - n/a

The development of stimuli‐responsive materials suitable for use in wearable sensors is a key unresolved challenge. Liquid crystals (LCs) are particularly promising, as they do not require power, are light‐weight, and can be tuned to respond to a range of targeted chemical stimuli. Here, an advance is reported in the design of LCs for chemical sensors with the discovery of LCs that assume parallel...

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Computational Chemistry‐Guided Design of Selective Chemoresponsive Liquid Crystals Using Pyridine and Pyrimidine Functional Groups

Huaizhe Yu, Tibor Szilvási, Prabin Rai, Robert J. Twieg, more

Advanced Functional Materials > 28 > 13 > n/a - n/a

Computational chemistry‐guided designs of chemoresponsive liquid crystals (LCs) with pyridine or pyrimidine groups that bind to metal‐cation‐functionalized surfaces to provide improved selective responses to targeted vapor species (dimethylmethylphosphonate (DMMP)) over nontargeted species (water) are reported. The LC designs against experiments are tested by synthesizing 4‐(4‐pentyl‐phenyl)‐pyridine...

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Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces

Timothy J. Smith, Chenxuan Wang, Nicholas L. Abbott

Journal of Colloid and Interface Science > 2017 > 502 > C > 122-133

We report experiments that test the hypothesis that redox-triggered changes in the architectures of surfactants permit control of mixing of surfactants within assemblies. Specifically, we describe surface tension, light scattering, atomic force microscopy, and quartz crystal microbalance measurements that characterize the redox-dependent behaviors of cationic surfactants with a ferrocene group located...

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Species variation and spatial differences in mucin expression from corneal epithelial cells

Brian C. Leonard, Bernardo Yañez-Soto, Vijay Krishna Raghunathan, Nicholas L. Abbott, more

Experimental Eye Research > 2016 > 152 > C > 43-48

Mucins are large glycoproteins expressed by epithelial cells of both the conjunctiva and cornea, and principle components of the glycocalyx. They are thought to play an important role in determining the interactions between the cornea/conjunctiva and the overlying tear film. The purpose of this study was to characterize the membrane-associated corneal mucin expression pattern from multiple species...

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Synthesis of Optically Complex, Porous, and Anisometric Polymeric Microparticles by Templating from Liquid Crystalline Droplets

Xiaoguang Wang, Emre Bukusoglu, Daniel S. Miller, Marco A. Bedolla Pantoja, more

Advanced Functional Materials > 26 > 40 > 7343 - 7351

It is demonstrated that aqueous dispersions of micrometer‐sized liquid crystal (LC) droplets provide the basis of a general and facile methodology for the templated synthesis of spherical and nonspherical polymeric microparticles with complex internal structure and porosity. Specifically, nematic droplets of reactive (RM257)/nonreactive mesogens with distinct internal configurations are prepared using...

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Using Chemoattractants to Lure Bacteria to Contact‐Killing Surfaces

Rishabh Jain, Nancy G. Faith, Andrew Milkowski, Kevin Nelson, more

Angewandte Chemie > 128 > 19 > 5792 - 5796

Antimicrobial surfaces with covalently attached biocidal functionalities only kill microbes that come into direct contact with the surfaces (contact‐killing surfaces). Herein, the activity of contact‐killing surfaces is shown to be enhanced by using gradients in the concentration of soluble chemoattractants (CAs) to attract bacteria to the surfaces. Two natural and nonbiocidal CAs (aspartate and glucose)...

article

Using Chemoattractants to Lure Bacteria to Contact‐Killing Surfaces

Rishabh Jain, Nancy G. Faith, Andrew Milkowski, Kevin Nelson, more

Angewandte Chemie International Edition > 55 > 19 > 5698 - 5702

Antimicrobial surfaces with covalently attached biocidal functionalities only kill microbes that come into direct contact with the surfaces (contact‐killing surfaces). Herein, the activity of contact‐killing surfaces is shown to be enhanced by using gradients in the concentration of soluble chemoattractants (CAs) to attract bacteria to the surfaces. Two natural and nonbiocidal CAs (aspartate and glucose)...

article

Active particles propelled into researchers’ focus

Nicholas L. Abbott, Orlin D. Velev

Current Opinion in Colloid & Interface Science > 2016 > 21 > C > 1-3

article

Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings

Kenneth S. Brandenburg, Diego F. Calderon, Patricia R. Kierski, Amanda L. Brown, more

Wound Repair and Regeneration > 23 > 6 > 842 - 854

Chronic nonhealing skin wounds often contain bacterial biofilms that prevent normal wound healing and closure and present challenges to the use of conventional wound dressings. We investigated inhibition of Pseudomonas aeruginosa biofilm formation, a common pathogen of chronic skin wounds, on a commercially available biological wound dressing. Building on prior reports, we examined whether the amino...

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Stimuli‐Responsive Cubosomes Formed from Blue Phase Liquid Crystals

Emre Bukusoglu, Xiaoguang Wang, Jose A. Martinez‐Gonzalez, Juan J. de Pablo, more

Advanced Materials > 27 > 43 > 6892 - 6898

Cubosomes formed from blue phase liquid crystals (BPs) dispersed in aqueous media exhibit optical responses to biological amphiphiles. In this study, the formation of aqueous dispersions of BPs is reported, and the effects of confinement and lipids on the phase behavior, optical appearance, and morphology of BP droplets are characterized.

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Sensors: Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers (Adv. Funct. Mater. 38/2015)

Monirosadat Sadati, Aslin Izmitli Apik, Julio C. Armas‐Perez, Jose Martinez‐Gonzalez, more

Advanced Functional Materials > 25 > 38 > 6147 - 6147

On page 6050, J. J. de Pablo and co‐workers demonstrate detection of Nanomolar concentrations of peptides by polarized light microscopy. Liquid crystals exhibit a specific response to beta‐sheet structures. The unstructured peptides involved in various diseases form beta‐sheet rich amyloid fibrils at lipid‐decorated liquid crystal interfaces, thereby altering the orientation of the underlying liquid...

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Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers

Monirosadat Sadati, Aslin Izmitli Apik, Julio C. Armas‐Perez, Jose Martinez‐Gonzalez, more

Advanced Functional Materials > 25 > 38 > 6050 - 6060

Liquid crystals (LCs) can serve as sensitive reporters of interfacial events, and this property has been used for sensing of synthetic or biological toxins. Here it is demonstrated that LCs can distinguish distinct molecular motifs and exhibit a specific response to beta‐sheet structures. That property is used to detect the formation of highly toxic protofibrils involved in neurodegenerative diseases,...

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Dynamic anchoring transitions at aqueous–liquid crystal interfaces induced by specific and non-specific binding of vesicles to proteins

Lie Na Tan, Nicholas L. Abbott

Journal of Colloid and Interface Science > 2015 > 449 > C > 452-461

This paper reports on the dynamics of continuous anchoring transitions at interfaces formed between nematic liquid crystals (LCs, 4′-pentyl-4-cyanobiphenyl (5CB)) and immiscible aqueous phases that are induced by either non-specific or specific interactions between phospholipid vesicles and proteins adsorbed at the LC interfaces. By analyzing the dynamic response of LCs to non-specific adsorption...

article

Importance of defining experimental conditions in a mouse excisional wound model

Shin Ae Park, Jill Covert, Leandro Teixeira, Monica J Motta, more

Wound Repair and Regeneration > 23 > 2 > 251 - 261

The murine dorsum dermal excisional wound model has been widely utilized with or without splint application. However, variations in experimental methods create challenges for direct comparison of results provided in the literature and for design of new wound healing studies. Here, we investigated the effects of wound location and size, number of wounds, type of adhesive used for splint fixation on...

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Reversible Switching of Liquid Crystalline Order Permits Synthesis of Homogeneous Populations of Dipolar Patchy Microparticles

Xiaoguang Wang, Daniel S. Miller, Juan J. de Pablo, Nicholas L. Abbott

Advanced Functional Materials > 24 > 39 > 6219 - 6226

The spontaneous positioning of colloids on the surfaces of micrometer‐sized liquid crystal (LC) droplets and their subsequent polymerization offers the basis of a general and facile method for the synthesis of patchy microparticles. The existence of multiple local energetic minima, however, can generate kinetic traps for colloids on the surfaces of the LC droplets and result in heterogeneous populations...

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Liquid Crystals Anchored on Mixed Monolayers of Chiral versus Achiral Molecules: Continuous Change in Orientation as a Function of Enantiomeric Excess

Yiqun Bai, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott

Angewandte Chemie > 126 > 31 > 8217 - 8221

The orientations of liquid crystals (LCs) anchored on monolayers formed from mixtures of chiral versus achiral molecules were compared. Changes in the enantiomeric excess of mixed monolayers of chiral dipeptides gave rise to continuous changes in the orientations of nematic LCs, allowing arbitrary tuning of the azimuthal orientations of LCs over a range of ≈100°. In contrast, the same LCs exhibited...

article

Liquid Crystals Anchored on Mixed Monolayers of Chiral versus Achiral Molecules: Continuous Change in Orientation as a Function of Enantiomeric Excess

Yiqun Bai, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott

Angewandte Chemie International Edition > 53 > 31 > 8079 - 8083

The orientations of liquid crystals (LCs) anchored on monolayers formed from mixtures of chiral versus achiral molecules were compared. Changes in the enantiomeric excess of mixed monolayers of chiral dipeptides gave rise to continuous changes in the orientations of nematic LCs, allowing arbitrary tuning of the azimuthal orientations of LCs over a range of ≈100°. In contrast, the same LCs exhibited...

INFONA - science communication portal

Search results for: Nicholas L. Abbott

Polymeric Films Containing Sodium Chlorite That Release Disinfectant Gas upon Activation with UV Light

Redox‐Triggered Orientational Responses of Liquid Crystals to Chlorine Gas

Redox‐Triggered Orientational Responses of Liquid Crystals to Chlorine Gas

Liquid Crystals with Interfacial Ordering that Enhances Responsiveness to Chemical Targets

Computational Chemistry‐Guided Design of Selective Chemoresponsive Liquid Crystals Using Pyridine and Pyrimidine Functional Groups

Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces

Species variation and spatial differences in mucin expression from corneal epithelial cells

Synthesis of Optically Complex, Porous, and Anisometric Polymeric Microparticles by Templating from Liquid Crystalline Droplets

Using Chemoattractants to Lure Bacteria to Contact‐Killing Surfaces

Using Chemoattractants to Lure Bacteria to Contact‐Killing Surfaces

Active particles propelled into researchers’ focus

Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings

Stimuli‐Responsive Cubosomes Formed from Blue Phase Liquid Crystals

Sensors: Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers (Adv. Funct. Mater. 38/2015)

Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers

Dynamic anchoring transitions at aqueous–liquid crystal interfaces induced by specific and non-specific binding of vesicles to proteins

Importance of defining experimental conditions in a mouse excisional wound model

Reversible Switching of Liquid Crystalline Order Permits Synthesis of Homogeneous Populations of Dipolar Patchy Microparticles

Liquid Crystals Anchored on Mixed Monolayers of Chiral versus Achiral Molecules: Continuous Change in Orientation as a Function of Enantiomeric Excess

Liquid Crystals Anchored on Mixed Monolayers of Chiral versus Achiral Molecules: Continuous Change in Orientation as a Function of Enantiomeric Excess

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