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Objective To describe the hypnotic effects of a single bolus dose of propofol in Japanese macaques, and to develop a pharmacokinetic model.
Study design Prospective experimental trial.
Animals Four male macaques (5–6 years old, 8.0–11.2 kg).
Methods The macaque was restrained and 8 mg kg−1 of propofol was administrated intravenously at 6 mg kg−1 minute−1. Behavioural changes without stimuli (first...
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