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The primary goal of this systematic review and meta‐analysis was to compare the efficacy and safety of fluoxetine with other oral pharmaceuticals in the treatment of premature ejaculation (PE). We searched through databases including CNKI, PubMed, EMBASE and Cochrane to find research published up to 31 March 2022. PROSPERO was used to pre‐register this meta‐analysis (registration number CRD42022315459)...
This study was to explore whether serotonin transporter gene‐linked polymorphic region polymorphisms (5‐HTTLPR+rs25531) influence the response to dapoxetine treatment in a Chinese population with premature ejaculation (PE). 112 patients with PE re‐enrolled from our previous study received dapoxetine monotherapy. At the endpoint, patients with S’S’ had a significant increased risk of nonresponse compared...
Limited evidence has indicated that brain‐derived neurotrophic factor (BDNF) may be involved in the neurobiology of premature ejaculation (PE). This study aimed to investigate BDNF levels in the central and peripheral nervous systems of a rapid ejaculation model. Eighteen male rats were selected and classified as ‘sluggish’, ‘normal’ and ‘rapid’ ejaculators on the basis of ejaculation frequency during...
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