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Bacteria‐induced epidemics and infectious diseases are seriously threatening the health of people around the world. In addition, antibiotic therapy has been inducing increasingly more serious bacterial resistance, which makes it urgent to develop new treatment strategies to combat bacteria, including multidrug‐resistant bacteria. Natural extracts displaying antibacterial activity and good biocompatibility...
The ability to effectively treat deep bacterial infections while promoting osteogenesis is the biggest treatment demand for diseases such as osteomyelitis. Microwave therapy is widely studied due to its remarkable ability to penetrate deep tissue. This paper focuses on the development of a microwave‐responsive system, namely, a zinc ion (Zn2+) doped graphite carbon nitride (CN) system (BZCN), achieved...
Dysfunctional transcription factors that activate abnormal expressions of specific proteins are often associated with the progression of various diseases. Despite being attractive drug targets, the lack of druggable sites has dramatically hindered their drug development. The emergence of proteolysis targeting chimeras (PROTACs) has revitalized the drug development of many conventional hard‐to‐drug...
Defect engineering is an important way to tune the catalytic properties of metal‐organic framework (MOF), yet precise control of defects is difficult to achieve. Herein, a cerium‐based MOF (CeTCPP) is decorated with Au nanoparticles. Under ultrasound irradiation, Au nanoparticles can precisely turn 1/3 of the pristine Ce3+ nodes into Ce4+. With the stable existence of Ce4+, the coordination of Ce...
In situ fabrication of macroscale ordered monolayers of nanoparticles (NPs) on targeted substrates is highly desirable for precision electronic and optical devices, while it remains a great challenge. In this study, a solution is provided to address this challenge by developing a colloidal ink formulation and employing the direct‐ink‐writing (DIW) technique, where on‐demand delivery of ink at a targeted...
It is difficult to effectively treat bacterial osteomyelitis using photothermal therapy or photodynamic therapy due to poor penetration of light. Here, a microwave (MW)‐excited magnetic composite of molybdenum disulfide (MoS2) / iron oxide (Fe3O4) is reported for the treatment of bacteria‐infected osteomyelitis. In in vitro and in vivo experiments, MoS2/Fe3O4 is shown to effectively eradicate bacteria‐infected...
Currently, nucleic acid aptamers are exploited as robust targeting ligands in the biomedical field, due to their specific molecular recognition, little immunogenicity, low cost, ect. Thanks to the facile chemical modification and high hydrophilicity, aptamers can be site‐specifically linked with hydrophobic moieties to prepare aptamer‐organic amphiphiles (AOAs), which spontaneously assemble into aptamer‐organic...
In article number 1902755, Xuemei Wang, Hui Jiang, and co‐workers demonstrate the aggregation of slight‐hollow gold silver nanocages by glutathione for both enhancement of photoacoustic signals at tumor sites and near infrared photothermal therapy. This work offers a new multifunctional strategy for efficient tumor theranostics.
Gold–silver nanocages (GSNCs) are widely used in cancer imaging and therapy due to excellent biocompatibility, internal hollow structures, and tunable optical properties. However, their possible responses toward the tumor microenvironment are still not well understood. In this study, it is demonstrated that a kind of relatively small sized (35 nm) and partially hollow GSNCs (absorbance centered at...
Functionalized hydrogels have aroused general interest due to their versatile applications in biomaterial fields. This work reports a hydrogel network composed of gold nanoclusters linked with bivalent cations such as Ca2+, Mg2+, and Zn2+. The hydrogel exhibits both aggregation‐induced emission (AIE) and aggregation‐induced electrochemiluminescence (AIECL) effects. Most noteworthy, the AIECL effect...
Cancer treatment has a far greater chance of success if the neoplasm is diagnosed before the onset of metastasis to vital organs. Hence, cancer early diagnosis is extremely important and remains a major challenge in modern therapeutics. In this contribution, facile and new method for rapid multimodal tumor bioimaging is reported by using biosynthesized iron complexes and gold nanoclusters via simple...
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