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On page 424, Srikanth Singamaneni and co‐workers introduce a new class of multifunctional plasmonic nanostructures for locoregional combination therapy of cancer cells and non‐invasive monitoring of the therapy process. This new class of responsive surface‐enhanced Raman scattering probes will look for a Raman signal “flip”, which indicates the completion of the therapy process and can potentially...
Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a “Raman signal flip” between the two reporters of the surface‐enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring...
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