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Mutations of vacuolar protein sorting‐associated protein 33b (VPS33B) cause arthrogryposis, renal dysfunction, and cholestasis syndrome, and a lack of platelet α‐granules in the affected patients. Conditional Vps33b knockout mice were developed to investigate the function(s) of Vps33b in platelet α‐granule formation. We found that early embryonic deletion of Vps33b was lethal. PF4‐Cre‐driven megakaryocyte‐targeted...
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