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Previous reports have demonstrated that N-l-leucyl-doxorubicin (LeuDox) is less toxic than its parent drug, Dox, but the underlying causes of this reduced toxicity have yet to be fully elucidated. In this study, the incorporation of LeuDox into (i) the MES-SA human uterine sarcoma cell line and (ii) its Dox resistant counterpart, MES-SA/Dx5 cell line and the subsequent transformation of LeuDox into...
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