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The highly conserved HLA-E is an effective inhibitory molecule for malignant cells in order to prevent their fate from NK cell killing. The few polymorphic HLA-E alleles are restricted to two functional variants HLA-E*01:01Arg107 and HLA-E*01:03Gly107, both of them have been described to present a limited set of peptides derived from class I leader sequences. We could previously demonstrate how the...
Over the last years, HLA-E has gained attention as an intermediate molecule for the innate and adaptive immune responses. Structural analysis of pHLA-E/NKG2 or pHLA-E/TCR complexes visualized fine-tuning of immune responses through single AA interaction between pHLA-E and its cognate receptor. Hence, it becomes important to understand the impact of subtle peptide differences especially in the context...
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