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The presence of circulating tumor cells (CTCs) in the vasculature directly correlates with the likelihood of metastasis development. Their rarity, however, makes them difficult to detect. Recently, the potential of photoacoustic (PA) imaging for sensitive detection of nanoparticle-targeted diseased cells has been demonstrated. However, the strong blood background can easily mask the weak signal from...
Magnetomotive photoacoustic imaging has been extended to address the problem of trapping and manipulating large micro-scale objects, mimicking circulating tumor cells, within a flow stream. Coupled contrast agents combining magneto-sensitive nanospheres and gold nanorods were targeted to 10 µm diameter polystyrene beads using amino acid conjugates to mimic targeting metastatic cancer cells circulating...
Photoacoustic (PA) imaging is rapidly evolving as a functional and molecular imaging tool. Contrast agents with high optical absorption, such as gold nanoparticles, have been used to target diseased cells and increase the specific contrast of PA imaging. However, background tissue absorption greatly limits the detection of PA signals and the specificity of these contrast agents. To sensitively identify...
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