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Microglia play a pivotal role in synaptic plasticity of chronic pain. In this study, the potential role of interleukin 1beta (IL-1β), mainly released by microglia in early stage of nerve injury, in mechanical allodynia induced by tetanic stimulation of the sciatic nerve (TSS) was examined. Mechanical allodynia was observed on both ipsilateral and contralateral sides of TSS. Moreover, the expression...
Microglia have been proposed to play a pivotal role by releasing proinflammatory cytokines in the central sensitization of spinal pain pathway. In the present study, we investigated the potential role of interleukin-18 (IL-18), mainly released by microglia, in the tetanic stimulation of the sciatic nerve (TSS)-induced mechanical allodynia of rats. TSS produced bilateral mechanical allodynia and the...
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