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Mas-related G-protein-coupled receptor subtype C (mouse MrgC11 and rat rMrgC), expressed specifically in small-diameter primary sensory neurons, may constitute a novel pain inhibitory mechanism. We have shown previously that intrathecal administration of MrgC-selective agonists can strongly attenuate persistent pain in various animal models. However, the underlying mechanisms for MrgC agonist-induced...
The activation of microglia and astrocytes in the spinal cord is involved in the progress of cancer pain. Propentofylline (PPF), a glial modulating agent, alleviates pain hypersensitivity in neuropathic pain models. The present study investigated the potential roles of PPF in a preclinical rat model of bone caner pain established by inoculating Walker 256 cells into the left tibia. At day 9 postinoculation,...
Microglia have been proposed to play a pivotal role by releasing proinflammatory cytokines in the central sensitization of spinal pain pathway. In the present study, we investigated the potential role of interleukin-18 (IL-18), mainly released by microglia, in the tetanic stimulation of the sciatic nerve (TSS)-induced mechanical allodynia of rats. TSS produced bilateral mechanical allodynia and the...
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