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Combination therapy has been recommended for the treatment of patients harboring multiple drug‐resistant hepatitis B virus (HBV). However, we recently demonstrated that monotherapy with tenofovir disoproxil fumarate (TDF) for 48 weeks displayed noninferior efficacy to TDF plus entecavir (ETV) combination therapy in patients with HBV resistant to multiple drugs, including ETV and adefovir. Nonetheless,...
Controversy exists about whether antiviral therapy (AVT) should be recommended for compensated cirrhosis patients with chronic hepatitis B virus (HBV) infection and detectable, but low, serum HBV‐DNA levels. A retrospective cohort of 385 treatment‐naïve, HBV‐related compensated cirrhosis patients (mean age: 51.1 ± 9.7 years; 66% male) with low HBV‐DNA levels (<2,000 IU/mL) was assessed for the...
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