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Oral squamous cell carcinoma (OSCC) is the most widespread malignant oral cavity neoplasm, with even higher proportion of deaths than breast cancer and cervical cancer. Although advances were made in conventional treatment for OSCC such as surgery and radiation therapy, there has not been significant increase in the 5-year survival rate in the past four decades, and chemotherapeutic drug resistance...
Hepatocellular carcinoma often evades effective therapy and recurrences are frequent. Recently, nanosecond pulsed electric field (nsPEF) ablation using pulse power technology has emerged as a local-regional, non-thermal, and non-drug therapy for skin cancers. In the studies reported here we use nsPEFs to ablate murine, rat and human HCCs in vitro and an ectopic murine Hepa 1–6 HCC in vivo. Using pulses...
Cancer continues to be a major risk to the health and well being among populations around the world. A new method using ion-ionizing radiation with nanosecond pulsed electric fields (nsPEFs) provides a novel means to treat cancer at local sites. NsPEFs promote cell death in several cell types and here we investigated mechanisms for cell death induction. In murine B16f10 melanoma, murine E4 squamous...
Summary form only given. Over the last several years pulse power technology has developed into a novel and innovative time domain nanotechnology as a new modality to treat cancer. The technology treats cancer in the absence of drugs by generating non-ionizing radiation with nanosecond pulsed electric fields (nsPEFs or nanopulses) that are high in power (gigawatts) and low in energy (millijoules)....
Our initial in vitro (HL-60 cells) and in vivo (B16-F10 murine) studies showed nanosecond pulsed electric fields (nsPEFs) caused intracellular changes and melanoma involution, respectively. We wanted to describe the morphologic changes in cell ultrastructure and investigate the mechanism for change due to nsPEFs in B16-F10 melanoma tumors in SKH-1 mice. We injected B16-F10 cells into 120 female SKH-1...
Ionizing radiation can be an environmental health risk as well as a cancer therapeutic, but similar roles for non-ionizing radiation are controversial. We have examined effects of wideband, intense non-ionizing radiation applied to cells and tissues as nanosecond pulsed electric fields (nsPEFs). Compared to conventional electroporation pulses, nsPEFs have shorter pulse durations (ges10 ns) and higher...
Applications of nanosecond pulsed electric fields (nsPEF) to human cells and mammalian tissues indicate that, as the pulse durations and/or the electric field intensities decrease, effects on the plasma membrane decrease and effects in intracellular signal transduction mechanisms increase. NsPEFs that are below the threshold for electroporation-like effects on the plasma membrane mimic cell-signaling...
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