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Inherited or acquired tamoxifen resistance is a major constraint in the endocrinological treatment of breast carcinomas. We developed an enzyme-immunoassay that discriminates between tamoxifen-sensitive and -resistant tumors. The procedure was established and standardized using two xenografted breast carcinomas – 3366 (highly sensitive to tamoxifen) and 3366/TAM (acquired tamoxifen resistance). The...
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