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Acute alcohol challenge studies in rodents and naturalistic observations in drinking alcoholics suggest that alcohol stimulates the hypothalamic–pituitary–adrenal (HPA) system. The literature on respective studies in healthy volunteers is more inconsistent, suggesting differential alcohol effects depending on dosage, recent drinking history, family history of alcoholism and alcohol‐induced side effects...
Rationale Acute alcohol effects may differ in social drinkers with a positive family history of alcohol use disorders (FHP) compared to FH negative (FHN) controls. Objectives To investigate whether FHP subjects prefer higher levels of brain alcohol exposure than do FHN controls. Materials and methods Twenty-two young healthy nondependent social drinkers participated in two identical sessions of...
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