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. Objective: To investigate whether lymphocytes could directly cause the destruction of bone cells in collageninduced arthritis (CIA) mice and the mechanism of this destruction. Methods: Arthritis was induced with chick type II collagen in Kunming mice. The activities of TNF-α and IFN-γ were measured by biological methods. The mRNA of TNF-α, IFN-γ, T-bet, a Th1 specific transcription factor and...
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