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Spine-associated Rap-specific GTPase-activating protein (SPAR) is a postsynaptic protein that forms a complex with postsynaptic density (PSD)-95 and N-methyl-d-aspartate receptors (NMDARs), and morphologically regulates dendritic spines. Mild intermittent hypoxia (IH, 16.0% O 2 , 4 h/day for 4 weeks) is known to markedly enhance spatial learning and memory in postnatal developing mice. Here,...
Hypoxia-induced outward currents (hyperpolarization) were examined in hippocampal CA1 neurons of rat brain slices, using the whole-cell recording technique. Hypoxic episodes were induced by perfusing slices with an artificial cerebrospinal fluid aerated with 5% CO 2 /95% N 2 rather than 5% CO 2 /95% O 2 , for about 3 min. The hypoxic current was consistently and reproducibly...
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