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Stimuli‐responsive nanoparticles, when injected systemically, circulate in the blood stream until reaching the site of myocardial infarction (MI). As reported by N. C. Gianneschi, K. L. Christman, and co‐workers on page 5547, recognition by infarct‐associated enzymes induces a morphology transition, triggering the subsequent aggregation of nanoparticles at the site of damage. The resulting microscale...
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme‐responsive peptide–polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical‐shaped, discrete materials to network‐like assemblies when acted upon by matrix metalloproteinases (MMP‐2...
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