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Slow conduction through the Purkinje-ventricular junction (PVJ) is thought to result in conduction block and ultimately re-entry under certain pathological conditions. The relationships between tissue structure, conduction velocity and the safety of conduction at such junctions however, are unknown. We developed an electrophysiologically detailed 3D model of the PVJ and varied the Purkinje fibre thickness...
We computationally evaluated the functional roles of atrial fibrillation induced electrical remodelling (AFER) on human atrial electrical excitations at cellular, tissue and whole organ levels. Our results show that AFER produced a dramatic reduction in action potential duration, slowing down of intra-atrial conduction, decrease in tissuepsilas temporal vulnerability, but remarkable increase in tissuepsilas...
We have developed a three-dimensional computational wedge model of canine cardiac ventricular wall electro-physiology that incorporates biophysically detailed, spatially heterogeneous excitation, and high-resolution geometry and fibre orientation. Isolated cell model electrophysiological characteristics reproduce the experimentally observed characteristics under control conditions, and under conditions...
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