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Background and purposeThe association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database.
MethodsIn 271 healthy subjects, 596 mild cognitive impairment patients and 197 AD patients, serum uric acid and CSF AD biomarkers were measured at baseline, and Mini‐Mental State Examination...
Background and purposeDisappointing outcomes from clinical trials involving amyloid‐modifying therapies for Alzheimer's disease (AD) have prompted more focus on the concept of early‐stage (E) amnestic mild cognitive impairment (E‐aMCI). However, limited evidence suggests that E‐aMCI may represent aMCI at a very early stage of AD. Furthermore, the nature of the progression of E‐aMCI to late‐stage aMCI...
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