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Asynchronous electrical activation, induced by bundle branch block (BBB), can cause reduced ventricular function. However, effects of BBB on the mechanical function of heart are difficult to assess experimentally. Based on an electromechanical canine heart model developed recently, the mechanical properties of complete LBBB and RBBB were simulated. The geometries and myofibre orientations of ventricles...
In this paper, we present a simulation study of transmural cellular electromechanical properties in heart failure based on a integrated and refined heart cell model of Luo-Rudy II model and modified Hunter-McCullochter Keurs mechanical model. The results show that prolonged action potential duration (APD) and APD rate-adaptation are more obviously transmurally heterogeneous in heart failure than those...
Based on our previously developed electrical heart model, an electromechanical biventricular model, which couples the electrical property and mechanical property of the heart, was constructed and the right ventricular wall motion and deformation was simulated using this model. The model was developed on the basis of composite material theory and finite element method. The excitation propagation was...
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