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A novel biosensor for ultra‐trace mRNA sensing was constructed based on isothermal circular strand‐replacement polymerization (CSRP) to amplify the electrochmeiluminescence (ECL) signal by combining quantum dots (CdTe) as luminophore. After the hairpin‐like capture DNA was opened by hybridization with target mRNA, the additive primer (DNA1) was able to get access to its complementary sequence which...
The cover picture shows a graphical image of an ultrasensitive mRNA biosensor, utilizing polymerase circle amplification strategy and quantum dots ECL system to achieve fmol detection limit. This neoteric technique could provide an integrated strategy for mRNA cancer marker during early detection. See the article by J. Li and H. Hai et al.; DOI: 10.1002/elan.201600590.
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