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The study aimed to clarify clinical significance of hepatitis B virus (HBV) rtA181S mutation in Chinese HBV‐infected patients. A total of 18 419 patients with chronic HBV infection from Beijing 302 Hospital were investigated. HBV complete reverse transcriptase region of polymerase was screened by direct sequencing, and the results were verified by clonal sequencing. Replication‐competent mutant and...
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