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Citrullination of joint proteins by the protein arginine deiminase (PAD) family of enzymes is recognized increasingly as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a novel PAD4‐selective inhibitor, GSK199, in the murine collagen‐induced arthritis model of rheumatoid arthritis. Mice were dosed daily from the time of collagen...
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