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The effects of methyl-deficiency and dietary restriction (DR) on hepatic cell proliferation and telomerase activity was studied in male Fischer 344 rats pretreated with aflatoxin B 1 (AFB 1 ). Five-week-old rats were gavaged 5 days per week for 3 weeks with AFB 1 (25 μg/rat per day) or solvent (100 μl 75% dimethylsulfoxide). Rats were then divided into four groups. Two groups...
Fourteen weeks-old male F344 rats maintained on a reduced calorie diet (60% of ad libitum (AL) food consumption) for 6 weeks or for 14 months did not affect the hepatic cell proliferation in terms of % S phase population, determined by evaluation of DNA synthesis in hepatocytes isolated from either young (5 months) or aged (18 months) rats. However, hepatic basal cellular DNA synthesis estimated...
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