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Background: In some previous studies, several restriction fragment length polymorphisms (RFLPs) in the lipoprotein lipase (LPL) gene were associated with coronary artery disease (CAD) and plasma lipid levels, but it is less clearly established in Japanese population. In this study, we examined the distribution of the LPL polymorphisms in a Japanese population and the associations between LPL polymorphisms...
Background: PONA is a HDL associated enzyme that hydrolyze organphosphates, carboxylic acids ester, and carbamate. Recently the association of coronary artery disease (CAD) and PONA activity were reported, and PONA genotype is considered as a new coronary risk factor. In this study we investigated the PONA genotype and susceptibility to oxidation of lipoproteins to elucidate the contribution of...
Background: Insulin resistance is a common finding in patients with coronary artery disease (CAD). Compensatory hyperinsulinemia and associated lipid disorders have been suggested to play an important role in the development of CAD. Troglitazone, a novel insulin sensitizing and antioxidant agent, may improve these metabolic disorders.Methods: We performed a standard 75 g oral glucose tolerance test...
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