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A series of recent reports has suggested PGC1α-driven upregulation of mitochondrial oxidative phosphorylation as a selective vulnerability of drug-resistant cancers. Accordingly, chemical inhibitors of respiration led to selective eradication of such cancer cells due to their preferential sensitivity to mitochondrial production of reactive oxygen species. These insights create a timely opportunity...
Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFα-dependent NFκB activation induces COP9 signalosome-mediated inhibition of GSK3β and the SCF β-TRCP ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.
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