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Brain iron levels are significantly increased in Parkinson’s disease (PD) and iron deposition is observed in the substantia nigra (SN) of PD patients. It is unclear whether iron overload is an initial cause of dopaminergic neuronal death or merely a byproduct that occurs in the SN of PD patients. In this study, ceruloplasmin knockout (CP−/−) mice and mice receiving an intracerebroventricular injection...
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