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The induction of premature mitosis by okadaic acid (OA) in HeLa cells in S-phase or in G 2 -phase has been studied using light microscopy, immunofluorescence, and immunochemical techniques. The observations indicate an involvement of a cdc2-independent pathway in these cells. It has been claimed that inhibition of an OA-sensitive phosphatase, possibly of PP1, induces activation of a kinase...
Okadaic acid has been shown to induce premature mitosis in HeLa cells belonging to both S-phase and G 2 -phase. The response is dependent on concentration and perhaps also on the differential susceptibility of cells to okadaic acid (OA). OA resembles caffeine in its ability to override the DNA-replication check point but differs in being capable of inducing premature mitosis in cells in G...
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