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Corticotrophin‐releasing hormone (CRH) neuroendocrine neurones in the paraventricular nucleus of the hypothalamus (PVH) drive adrenocorticotrophic hormone (ACTH) and thereby glucocorticoid release from pituitary corticotrophs and the adrenal cortex, respectively. Glucocorticoids suppress the ability of neuroendocrine corticotrophin‐releasing hormone (CRH) neurones to synthesise and release ACTH secretogogues...
Increasing evidence indicates that the cAMP responsive element binding protein (CREB)‐dependent transcriptional activation of a number of genes requires the CREB co‐activator: transducer of regulated CREB activity (TORC). Because of the central importance of CREB in many brain functions, we examined the topographic distribution of TORC1, 2, and 3 mRNAs in specific regions of the rat forebrain. In situ...
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