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Reproductive and endocrine disruption is commonly reported in aquatic species exposed to complex contaminant mixtures. We previously reported that Atlantic killifish (Fundulus heteroclitus) from the chronically contaminated Newark Bay, NJ, exhibit multiple endocrine disrupting effects, including inhibition of vitellogenesis (yolk protein synthesis) in females and false negative vitellogenin biomarker...
The morphology and function of rat GH3 pituitary cells are profoundly affected by estradiol-17β (E2), presumably due to changes in the profile of gene expression. We recently reported that a major target of E2 in these cells is the ezrin gene, which encodes a cytoskeletal linker protein that forms a complex with ezrin/radixin/moesin-binding protein 50 (EBP50) in some cell types. Other studies have...
The antiestrogen, ICI 182780, and estradiol-17β (E2) regulate cadherin-mediated cell adhesion in pituitary GH3 cells. Using a cDNA expression array to screen for E2-regulated genes that are associated with the cytoskeleton, we observed that E2 stimulated ezrin gene expression and confirmed that ezrin gene expression is regulated pretranslationally by ICI 182780 versus E2. E2 increased ezrin protein...
The ability of the estrogen receptor signaling pathway to regulate cell-cell adhesion, and N-cadherin and β-catenin expression was examined in rat somatolactotropic GH3 cells cultured in serum-free, phenol red-free medium (SFM). Estradiol-17β (E2) promoted a nonadherent phenotype, whereas the steroidal anti-estrogen, ICI 182,780, induced the formation of tightly adherent aggregates of cells. The antiestrogen-induced...
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