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Sonophoresis which utilizes ultrasound for transdermal drug delivery (TDD), can increase the skin permeability and improve the efficiency of drug delivery to various drugs. In addition, the addition of microbubbles in sonophoresis accelerate and increase an efficiency of drug delivery. The cavitation induced by sonophoresis with microbubbles on the skin surface may cause disordering of the lipid bilayers...
In this study, we investigated the gene delivery efficiency of ultrasound sonication on plasmid DNA prior to transfection. The transfection efficiencies of the normal pEGPF (concentration of 500ng/well), and the pEGPF applied ultrasound were evaluated by transfection experiment with lipofectamineTM 2000 (Invitrogen) to CT26 cell. The 4.2-kbp pEGFP-C1 (Roche Applied Science) were amplified in Escherichia...
Sonophoresis for transdermal drug delivery(TDD) generally uses relatively low frequency ultrasound (e.g., <100 kHz). The main mechanism of sonophoresis is related to cavitation of bubbles trapped between ultrasound transducer and skin. Thus, enhancement of cavitation can lead to effective TDD. In this presentation, the efficacy of TDD with ultrasound contrast agent(UCA) was tested by animal experiments...
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