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Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections. Novel therapeutic strategies are needed to improve anti-biofilm efficacy and support reduction in antibiotic use. Treatment with exogenous nitric oxide (NO) has been shown to modulate bacterial signaling and metabolic processes that render...
Just say NO to biofilms: NO‐donors are used to disperse a bacterial biofilm so that co‐administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin‐3′‐diazeniumdiolate NO‐donor prodrug (see scheme) is activated by bacterial β‐lactamases and facilitates this two‐step biofilm erradication.
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