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The purpose of this study was to evaluate the relationship between calcification in tibial arteries, the degree of limb ischemia, and the near-term risk of amputation.Determining the amputation risk in patients with peripheral arterial disease (PAD) remains difficult. Developing new measures to identify patients who are at high risk for amputation would allow for targeted interventions and focused...
Background: Sleep disturbances are common side effects of betablockers. In order to investigate the influence of these drugs on melatonin production we performed a randomized, double-blind, placebo-controlled, cross-over study in 15 healthy volunteers.Methods: Subjects received single oral doses of 40 mg (R)-propanolol, 40 mg (S)-propanolol, 50 mg (R)-atenolol, 50 mg (S)-atenolol, 25 mg (R,S)-carvedilol...
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