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The importance of costimulation on CD4+ T cells has been well documented. However, primary CTLs against many infections including influenza can be generated in the absence of CD4+ T‐cell help. The role of costimulation under such “helpless” circumstances is not fully elucidated. Here, we investigated such a role for CD28 using CTLA4Ig transgenic (Tg) mice. To ensure valid comparison across the genotypes,...
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