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Purpose The aim of the present study was to assess whether two widely used biomarkers for 5-HT1A-receptor mediated responses in the rat (hypothermia and corticosterone increase) could be scaled to man using allometric principles. Materials and Methods Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) models were developed and characterized in rats for the standard 5-HT1A-receptor agonists,...
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