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Postnatal treatment with the selective serotonin reuptake inhibitor fluoxetine, evokes anxiety and depressive behavior in rodent models in adulthood. We examined the role of serotonin 2A (5-HT 2A ), serotonin 2C (5-HT 2C ) and serotonin 1A (5-HT 1A ) receptors, implicated in the development of anxiety, in the behavioral consequences of postnatal fluoxetine (PNFlx).Control and...
Immobilization stress decreases the expression of BDNF mRNA in the rat hippocampus, and this effect could contribute to the atrophy of hippocampal neurons. This study examines the influence of selective 5-HT, as well as norepinephrine, receptor antagonists on the stress-induced down-regulation of BDNF mRNA. Pretreatment with a selective 5-HT 2A receptor antagonist, MDL100,907, significantly...
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