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Leukemia inhibitory factor (LIF) has pleiotropic effects on bone. To determine how LIF may modulate osteoblast activity, we have examined which signal transduction pathways are implicated in the induction of the c-fos protooncogene in the human osteoblast-like cell line, TE-85. The promoter of the c-fos gene contains several domains which are targets for intracellular signaling cascades: the Ca...
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