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The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive elements (VDREs). VDREs in positively controlled genes such as osteocalcin, osteopontin, β 3 -integrin, and vitamin D-24-OHase are direct hexanucleotide...
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